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A clerodane diterpene (plaunol A) and three flavonoids (vitexin; luteolin-7-O-β-D-glucoside and luteolin-4'-O-glucoside) were isolated from stems and leaves of Croton stellatoliosus Ohba, using series of chromatographic techniques. Evaluation for anti-inflammatory… Click to show full abstract
A clerodane diterpene (plaunol A) and three flavonoids (vitexin; luteolin-7-O-β-D-glucoside and luteolin-4'-O-glucoside) were isolated from stems and leaves of Croton stellatoliosus Ohba, using series of chromatographic techniques. Evaluation for anti-inflammatory activity in LPS-induced RAW264.7 cells revealed that, only plaunol A exhibited the inhibitory activity on nitric oxide production with the IC50 of 11.69 μM. This was no cytotoxic effect to the cells at a concentration of 100 μM, by MTT assay. Determination of mRNA levels by qRT-PCR, indicated that plaunol A suppressed the expressions of inducible nitric oxide synthase and cyclooxygenase-2 in lipopolysaccharide-induced RAW264.7 cells.
Journal Title: Natural Product Communications
Year Published: 2018
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