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A new limonoid, 6α,7α-diacetoxy-3-oxo-24,25,26,27-tetranorapotirucalla-1,14,20(22)-trien-21,23-lactam (1), was isolated from the fruits of Chsocheton paniculatus Hiern collected in Vietnam, together with two known 5α,8α-epidioxysterols, (22E,24R)-5α,8α-epidioxy-24-methyl-cholesta-6,22-dien-3β-ol (2) and (22E,24R)-5α,8α-epidioxy-24-methyl-cholesta-6,9(11),22-trien-3β-ol (3) Their structures were… Click to show full abstract
A new limonoid, 6α,7α-diacetoxy-3-oxo-24,25,26,27-tetranorapotirucalla-1,14,20(22)-trien-21,23-lactam (1), was isolated from the fruits of Chsocheton paniculatus Hiern collected in Vietnam, together with two known 5α,8α-epidioxysterols, (22E,24R)-5α,8α-epidioxy-24-methyl-cholesta-6,22-dien-3β-ol (2) and (22E,24R)-5α,8α-epidioxy-24-methyl-cholesta-6,9(11),22-trien-3β-ol (3) Their structures were elucidated by spectroscopic analyses, including D- and 2D-NMR and HRESIMS, and comparisons with the reported data in the literature. Compounds 1–3 exhibited the NO production inhibitory activities against the LPS stimulated BV2 cells with 69.0 ± 2.7 %, 69.5 ± 2.2 %, and 70.6 ± 1.6 %, at concentration of 20.0 μM, respectively.
Journal Title: Natural Product Communications
Year Published: 2018
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