Photo by robertbye from unsplash
A new chlorinated polyketide setosphaerine A (1), together with 3 known ones penicipyran D (2), 7-O-demethymonocerin (3), and monocerin (4), was isolated from the entomogenous fungus Setosphaeria rostrata. The structure… Click to show full abstract
A new chlorinated polyketide setosphaerine A (1), together with 3 known ones penicipyran D (2), 7-O-demethymonocerin (3), and monocerin (4), was isolated from the entomogenous fungus Setosphaeria rostrata. The structure of compound 1 was established on the basis of 1D/2D Nuclear Magnetic Resonance (NMR) spectroscopic and High Resolution Electro Spray Ionization Mass Spectra (HR-ESI-MS) data. Compounds 1 to 4 showed moderate cytotoxicity against 3 human tumor cell lines MCF-7, MGC-803, and Hela with IC50 values ranging from 33 to 243 nM.
Journal Title: Natural Product Communications
Year Published: 2019
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!