LAUSR

Purification of the petroleum ether and ethyl acetate fractions from Ludwigia hyssopifolia yielded 9 natural products, ethyl gallate (1), vanillin (2), trans-p-hydroxycinnamic acid (3), trans-p-hydroxy-ethyl cinnamate (4), ozoroalide (5), scopoletin (6), de-O-methyllasiodiplodin (7), syringaldehyde (8), and 3,3′-dimethoxy-4,4′-dihydroxy-stilbene (9). The structures of 1 to 9 were determined by spectroscopic analyses including 1D Nuclear Magnetic Resonance (NMR) (1H NMR and 13C NMR) and Mass Spectrum (MS) data. Four compounds displayed cytotoxic effects on the human laryngeal cancer Hep-2 cell line. Compounds 5 and 7 were also effective against TU212 cell line and significantly inhibited cancer cell growth in a dose- and time-dependent manner on Hep-2 cell line.