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A new cucurbitane-type glycoside (1) and two known compounds (2-3) were isolated from the ethanol extract of the fruits of Momordica charantia L. Their chemical structures were determined as (19S,23E)-5β,19-epoxy-19-methoxycucurbita-6,23-diene-3β,25-diol… Click to show full abstract
A new cucurbitane-type glycoside (1) and two known compounds (2-3) were isolated from the ethanol extract of the fruits of Momordica charantia L. Their chemical structures were determined as (19S,23E)-5β,19-epoxy-19-methoxycucurbita-6,23-diene-3β,25-diol 3-O-β-D-allopyranoside (1), goyaglycoside d (2), and (19S,23E)-5β,19-epoxy-19-methoxycucurbita-6,23-diene-3β,25-diol (3) on the basis of the extensive spectroscopic methods, including 1D, 2D NMR, HRESIMS, and in comparison with the reported data. Compounds 1 to 3 were evaluated for α-glucosidase inhibitory effects. Compounds 1 and 2 showed anti α-glucosidase activity with IC50 values of 134.12 ± 11.20 and 163.17 ± 13.71 µM, respectively, compared with the positive control, acarbose, IC50 160.99 ± 14.30 μM. Compounds 2 and 3 were first isolated from plant M. charantia growing in Vietnam.
Journal Title: Natural Product Communications
Year Published: 2022
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