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Trichloroethylene increases pulmonary endothelial permeability: implication for pulmonary veno-occlusive disease

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Trichloroethylene exposure is a major risk factor for pulmonary veno-occlusive disease. We demonstrated that trichloroethylene alters the endothelial barrier integrity, at least in part, through vascular endothelial (VE)-Cadherin internalisation, and… Click to show full abstract

Trichloroethylene exposure is a major risk factor for pulmonary veno-occlusive disease. We demonstrated that trichloroethylene alters the endothelial barrier integrity, at least in part, through vascular endothelial (VE)-Cadherin internalisation, and suggested that this mechanism may play a role in the development of pulmonary veno-occlusive disease.

Keywords: occlusive disease; trichloroethylene; veno occlusive; pulmonary veno

Journal Title: Pulmonary Circulation
Year Published: 2020

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