LAUSR

Dear Sir Heart diseases mostly are age-related disorders. Such conditions deteriorate after intense labor or in cold weather, suggesting that energy metabolism may be one of the causal factors in addition to genetic predisposition. Men have higher risks of coronary heart disease than women as males tend to have more robust energy metabolism. As people age, the respiratory chain for adenosine triphosphate production may be attenuated, but still with a normal ongoing Krebs cycle. The buildup of insoluble and rigid calcium salts of organic acids via the Krebs cycle may trigger cardiovascular diseases, as short chain organic acids possess modest median lethal doses in animals. Recent hypotheses suggest that oxalate could be one important causal factor, which can be produced from the shunt of Krebs cycle and other pathways. Settlements of patients in warmer regions are advantaged as energy metabolism is decreased, reducing concentrations of short chain organic acids. Heating in cold winter months is hugely beneficial. It is worth noting that some patients may be sensitive to high humidity. As well, other preventive measures include plant-based and fish-based diet, moderate intake of wines and olive oil, intake of vinegar, etc. Caution should be exercised in the intake of NaCl as some salts may contain relatively high amounts of divalent cations, which are prone to form insoluble salts.