LAUSR

Common variable immunodeficiency (CVID) is a complex primary immunodeficiency disorder with hypogammaglobulinemia as a major feature. Most of the patients do not have a specific genetic abnormality. Autoimmune disorders occur commonly in patients with CVID. We report a case of a girl with secondary adrenal insufficiency who developed a disseminated varicella zoster infection and zoster meningoencephalitis with vaccine strain. The laboratory evaluation of this patient led to the final diagnosis of CVID with a new variant of TACI (transmembrane activator and calcium-modulator and cyclophilin ligand interactor) mutation and DAVID syndrome (deficit of anterior pituitary function and variable immune deficiency).1