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In this issue of Blood , Yoshimi et al describe a simple method to establish patient-derived xenografts (PDXs) of chronic myelomonocytic leukemia (CMML) and juvenile myelomonocytic leukemia (JMML) with remarkable… Click to show full abstract
In this issue of Blood , Yoshimi et al describe a simple method to establish patient-derived xenografts (PDXs) of chronic myelomonocytic leukemia (CMML) and juvenile myelomonocytic leukemia (JMML) with remarkable efficiency. These morphologically, immunophenotypically, and genetically accurate models will pave the way for in vivo biological studies and preclinical testing of novel therapies. 1