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To the editor: Germ line–activating mutations of protein tyrosine phosphatase PTPN11 (Shp2), a positive regulator of the Ras signaling pathway,[1][1] account for more than 50% of patients with Noonan syndrome.[2][2]… Click to show full abstract
To the editor: Germ line–activating mutations of protein tyrosine phosphatase PTPN11 (Shp2), a positive regulator of the Ras signaling pathway,[1][1] account for more than 50% of patients with Noonan syndrome.[2][2] These patients have an increased risk of developing leukemias,[3][3] especially
Keywords:
ptpn11;
ccl3 key;
activating mutations;
key mediator;
leukemogenic effect;
mediator leukemogenic
Journal Title: Blood
Year Published: 2017
Link to full text (if available)
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Journal Title: Blood
Year Published: 2017
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!