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In this issue of Blood , Ghia et al observe that a proportion of patients with chronic lymphocytic leukemia (CLL) harbor mutations in genes involved in the Hedgehog (Hh) pathway… Click to show full abstract
In this issue of Blood , Ghia et al observe that a proportion of patients with chronic lymphocytic leukemia (CLL) harbor mutations in genes involved in the Hedgehog (Hh) pathway resulting in expression of glioma-associated oncogene homolog 1 (GLI1). They also find that GLI1 is expressed in CLL cells without evidence of Hh mutations and that the high GLI1 levels correlate with disease progression. 1
Keywords:
cll;
activation cll;
hedgehog activation
Journal Title: Blood
Year Published: 2019
Link to full text (if available)
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Journal Title: Blood
Year Published: 2019
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!