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Truncation mutations in the granulocyte colony-stimulating factor receptor gene (CSF3R) are a rare abnormality in pediatric acute myeloid leukemia, and are usually associated either with mutations in CEBPA or with… Click to show full abstract
Truncation mutations in the granulocyte colony-stimulating factor receptor gene (CSF3R) are a rare abnormality in pediatric acute myeloid leukemia, and are usually associated either with mutations in CEBPA or with t(8;21). Through sequencing of over 2000 patients, the authors demonstrated that, although CSF3R mutations with associated t(8;21) still had an excellent response, CSF3R mutation abrogated the favorable risk of CEBPA mutation alone.
Keywords:
myeloid leukemia;
favorable risk;
csf3r;
acute myeloid;
csf3r mutations
Journal Title: Blood
Year Published: 2020
Link to full text (if available)
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Journal Title: Blood
Year Published: 2020
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!