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Combination dose-escalated hydroxyurea and transfusion: an approach to conserve blood during the COVID-19 pandemic

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Nickel et al describe a single-arm trial using dose-escalated hydroxyurea and regular transfusions to prevent complications of sickle cell anemia. Preliminary results suggest that a reduction in volume of red… Click to show full abstract

Nickel et al describe a single-arm trial using dose-escalated hydroxyurea and regular transfusions to prevent complications of sickle cell anemia. Preliminary results suggest that a reduction in volume of red cell requirements may be achievable.

Keywords: combination dose; transfusion approach; hydroxyurea transfusion; blood; dose escalated; escalated hydroxyurea

Journal Title: Blood
Year Published: 2020

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