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Red cell–bound antibodies and transfusion requirements in hospitalized patients with COVID-19

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Berzuini et al report the observation that nearly half of patients with COVID-19 tested at their blood center had a positive direct antiglobulin test (DAT). However, eluates did not react… Click to show full abstract

Berzuini et al report the observation that nearly half of patients with COVID-19 tested at their blood center had a positive direct antiglobulin test (DAT). However, eluates did not react with any test cells but did react with red cells from other patients with COVID-19 that were DAT negative. This suggests that COVID-19 may modulate the red cell membrane and present novel antigenic epitopes.

Keywords: red cell; bound antibodies; antibodies transfusion; patients covid; cell bound

Journal Title: Blood
Year Published: 2020

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