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Kaiser et al investigated how platelets contribute to vascular integrity during inflammation. They show that single migrating platelets become procoagulant, recruiting the coagulation cascade to prevent pulmonary inflammatory bleeding. This… Click to show full abstract
Kaiser et al investigated how platelets contribute to vascular integrity during inflammation. They show that single migrating platelets become procoagulant, recruiting the coagulation cascade to prevent pulmonary inflammatory bleeding. This protective action is triggered by encounters with subendothelial collagen and is mediated via glycoprotein (GP) IIBIIIA and GPVI signaling. Blockade of this integrin signaling aggravates inflammatory pulmonary hemorrhage, suggesting relevance to clinical scenarios.
Journal Title: Blood
Year Published: 2022
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