Arruda et al review the alloimmune and autoimmune responses to procoagulant factors that cause serious bleeding and the important, unresolved problems of how to prevent and treat these conditions. They… Click to show full abstract
Arruda et al review the alloimmune and autoimmune responses to procoagulant factors that cause serious bleeding and the important, unresolved problems of how to prevent and treat these conditions. They integrate the underlying pathophysiology with relevant clinical findings and outcomes with current treatment approaches while highlighting preclinical developments that are being explored and that may lead to new treatments.
               
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