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Association between the HLA-DRB1*03:01-DQB1*02:01 haplotype and PF4/heparin antibodies.

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HLA-DRB1*03:01-DQB1*02:01 haplotype patients develop higher anti–platelet factor 4/heparin (PF4/H) levels following IV heparin exposure. HLA-restricted antigen presentation may play a role in the formation of anti-PF4/H antibodies. Click to show full abstract

HLA-DRB1*03:01-DQB1*02:01 haplotype patients develop higher anti–platelet factor 4/heparin (PF4/H) levels following IV heparin exposure. HLA-restricted antigen presentation may play a role in the formation of anti-PF4/H antibodies.

Keywords: drb1 dqb1; dqb1 haplotype; hla drb1

Journal Title: Blood advances
Year Published: 2019

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