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IL-6 levels are dramatically high in the sputum from children with sickle cell disease during acute chest syndrome.

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Sputum interleukin-6 (IL-6) level is high during acute chest syndrome (ACS) in pediatric sickle cell disease, supporting anti–IL-6 trials. Sputum IL-8, CCL2, and CCL3 levels are also high during ACS,… Click to show full abstract

Sputum interleukin-6 (IL-6) level is high during acute chest syndrome (ACS) in pediatric sickle cell disease, supporting anti–IL-6 trials. Sputum IL-8, CCL2, and CCL3 levels are also high during ACS, possibly contributing to recruitment of inflammatory cells in the lungs.

Keywords: sputum; cell disease; acute chest; sickle cell; chest syndrome

Journal Title: Blood advances
Year Published: 2020

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