LAUSR

BACKGROUND Patients with an inferior vena cava (IVC) filter that remains in situ encounter a lifelong increased risk of deep vein thrombosis and IVC filter complications including fracture, perforation and IVC filter thrombotic occlusion. Data on the safety of becoming pregnant with an in situ IVC filter are scarce. OBJECTIVE To evaluate the risk of complications of in situ IVC filters during pregnancy. METHODS We performed a retrospective cohort study of pregnant patients with an in situ IVC filter from a tertiary center between 2000 and 2020. We collected data on complications of IVC filters and pregnancy outcomes. Additionally, we performed a systematic literature search in MEDLINE, Embase and grey literature. FINDINGS We identified seven pregnancies in four patients with in situ IVC filters with a mean time since IVC filter insertion of 3 years (range 1-8). No complications of IVC filter occurred during pregnancy. Review of literature yielded five studies including 13 pregnancies in nine patients. In one pregnancy a pre-existent, until then asymptomatic, chronic perforation of the vena cava wall by the IVC filter caused major bleeding and uterine trauma with fetal loss. Overall, the complication rate was 5%. CONCLUSION It seems safe to become pregnant with an indwelling IVC filter that is intact and does not show signs of perforation, but due to the low number of cases no firm conclusions about safety of in situ IVC filters during pregnancy can be drawn. We suggest imaging prior to pregnancy to reveal asymptomatic IVC filter complications.