"Differential regulation of CTLA4 expression through BTK-dependent and independent mechanisms in CLL"

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Key Points Ibrutinib suppresses CLL cell CTLA4 expression in vitro and in vivo. CTLA4 expression on CLL is regulated by non-BTKs that differ from T-cell CTLA4 regulation. Click to show full abstract

Key Points Ibrutinib suppresses CLL cell CTLA4 expression in vitro and in vivo. CTLA4 expression on CLL is regulated by non-BTKs that differ from T-cell CTLA4 regulation.

Keywords: ctla4 expression; ctla4; differential regulation; regulation ctla4

Journal Title: Blood Advances
Year Published: 2022

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