Key Points IFNγ induces a highly oxidative metabolic phenotype with high rates of oxygen consumption by both mitochondria and NADPH oxidase. IFNγ induces a NAMPT-dependent, NAD+ salvage pathway that is… Click to show full abstract
Key Points IFNγ induces a highly oxidative metabolic phenotype with high rates of oxygen consumption by both mitochondria and NADPH oxidase. IFNγ induces a NAMPT-dependent, NAD+ salvage pathway that is required for complete induction of the respiratory burst in human monocytes.
               
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