LAUSR

Pregnant women with sickle cell disease (SCD) are at an increased risk for both pregnancy and SCD related morbidity and mortality in low, middle, and high-income countries. 1 The maternal death rate in pregnant women with SCD in sub-Saharan Africa is 7% to 12%. 2-4 At the Korle-Bu Teaching Hospital (KBTH), a national referral center in Accra, Ghana, the maternal and perinatal mortality rates were 10791 per 100000 live births (case fatality rate: 9.5%) and 60.8 per 1000 total births, respectively, between January 2014 and April 2015. 5 In the most common cause of death in the current study; 2 pregnant women with HbSC phenotype had a clinical diagnosis of rapidly progressive ACS 10 with multiorgan failure, requiring ventilatory support. 10 Both women developed thrombocytopenia ( , 80000/ m L), multiorgan failure (hepatic dysfunction, coagulopathy), altered mental status, and stroke.