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Megakaryocyte/platelet-derived TGF-β1 inhibits megakaryopoiesis in bone marrow by regulating thrombopoietin production in liver

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Key Points Loss of Tgfb1 expression in MKs increases MK production in BM and TPO expression in the liver. Inhibition of TGF-β1 might increase MK generation in vivo and in… Click to show full abstract

Key Points Loss of Tgfb1 expression in MKs increases MK production in BM and TPO expression in the liver. Inhibition of TGF-β1 might increase MK generation in vivo and in vitro.

Keywords: tgf inhibits; megakaryocyte platelet; production; inhibits megakaryopoiesis; platelet derived; derived tgf

Journal Title: Blood Advances
Year Published: 2022

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