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The differential role of the lipid raft-associated protein flotillin 2 for progression of myeloid leukemia

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Key Points The lipid raft protein flotillin 2 differentially influences disease course in murine CML, but not AML. The flotillin 2-CD44-CDC42 axis regulates CML via an impact on the cytoskeleton… Click to show full abstract

Key Points The lipid raft protein flotillin 2 differentially influences disease course in murine CML, but not AML. The flotillin 2-CD44-CDC42 axis regulates CML via an impact on the cytoskeleton and homing ability of leukemia- initiating cells.

Keywords: lipid raft; role lipid; leukemia; differential role; protein flotillin

Journal Title: Blood Advances
Year Published: 2022

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