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Hypermethylation at the CXCR5 gene locus limits trafficking potential of CD8+ T cells into B-cell follicles during HIV-1 infection

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Key Points A paucity of follicular CD8+ T cells in LN germinal centers contributes to HIV persistence during cART. CXCR5 expression in human CD8+ T cells is tightly regulated by… Click to show full abstract

Key Points A paucity of follicular CD8+ T cells in LN germinal centers contributes to HIV persistence during cART. CXCR5 expression in human CD8+ T cells is tightly regulated by epigenetic mechanisms.

Keywords: cd8 cells; gene locus; locus limits; cxcr5 gene; hypermethylation cxcr5; cd8

Journal Title: Blood Advances
Year Published: 2022

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