Key Points scRNAseq identifies two CD4+ GM-CSF+ T-cell subsets in the colon during GVHD that can be distinguished based on expression of IFN-γ. CD4+ GM-CSF+ IFN-γ− T cells constitute an… Click to show full abstract
Key Points scRNAseq identifies two CD4+ GM-CSF+ T-cell subsets in the colon during GVHD that can be distinguished based on expression of IFN-γ. CD4+ GM-CSF+ IFN-γ− T cells constitute an IL-7–responsive, transcriptionally and developmentally distinct colitogenic TH GM-CSF + lineage.
               
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