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Single-cell immune profiling reveals a developmentally distinct CD4+ GM-CSF+ T-cell lineage that induces GI tract GVHD

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Key Points scRNAseq identifies two CD4+ GM-CSF+ T-cell subsets in the colon during GVHD that can be distinguished based on expression of IFN-γ. CD4+ GM-CSF+ IFN-γ− T cells constitute an… Click to show full abstract

Key Points scRNAseq identifies two CD4+ GM-CSF+ T-cell subsets in the colon during GVHD that can be distinguished based on expression of IFN-γ. CD4+ GM-CSF+ IFN-γ− T cells constitute an IL-7–responsive, transcriptionally and developmentally distinct colitogenic TH GM-CSF + lineage.

Keywords: cd4 csf; cell; csf cell; developmentally distinct

Journal Title: Blood Advances
Year Published: 2022

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