Key Points Elevated IRF8 in granulocyte-monocyte progenitors from Gata2 −77 enhancer mutant embryos cause macrophage-biased differentiation. Genetically ablating Irf8 reverses fetal liver hematopoiesis defects of Gata2 enhancer mutant embryos, thus… Click to show full abstract
Key Points Elevated IRF8 in granulocyte-monocyte progenitors from Gata2 −77 enhancer mutant embryos cause macrophage-biased differentiation. Genetically ablating Irf8 reverses fetal liver hematopoiesis defects of Gata2 enhancer mutant embryos, thus establishing a GATA2-IRF8 axis.
Keywords:
elevates interferon;
gata2 deficiency;
interferon regulatory;
differentiation;
deficiency elevates;
regulatory factor
Journal Title: Blood Advances
Year Published: 2022
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Journal Title: Blood Advances
Year Published: 2022
Link to full text (if available)
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recommendations!