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The TΑp63/BCL2 axis represents a novel mechanism of clinical aggressiveness in chronic lymphocytic leukemia

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Key Points High expression of TAp63 is linked to adverse clinical outcomes in CLL. TAp63 contributes to the antiapoptotic phenotype of CLL cells, likely through modulating BCL2 protein expression. Click to show full abstract

Key Points High expression of TAp63 is linked to adverse clinical outcomes in CLL. TAp63 contributes to the antiapoptotic phenotype of CLL cells, likely through modulating BCL2 protein expression.

Keywords: mechanism clinical; axis represents; represents novel; novel mechanism; p63 bcl2; bcl2 axis

Journal Title: Blood Advances
Year Published: 2022

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