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Key Points A missense mutation in LCP1, an actin-bundling protein, results in severe neutropenia, migration defects, and susceptibility to infection. LCP1 mutation causes actin dysregulation with increased F-actin, G2/M cell… Click to show full abstract
Key Points A missense mutation in LCP1, an actin-bundling protein, results in severe neutropenia, migration defects, and susceptibility to infection. LCP1 mutation causes actin dysregulation with increased F-actin, G2/M cell cycle arrest, dysplastic cells, and nuclear mislocalization.
Keywords:
lymphocyte cytosolic;
protein plastin;
i232f mutation;
plastin i232f;
mutation;
cytosolic protein
Journal Title: Blood Advances
Year Published: 2022
Link to full text (if available)
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Journal Title: Blood Advances
Year Published: 2022
Link to full text (if available)
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recommendations!