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Complement gene variant effect on relapse of complement-mediated thrombotic microangiopathy after eculizumab cessation

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Key Points • In CM-TMA, variants in specific genes/regions are associated with high risk of relapse after eculizumab is discontinued.• In CM-TMA, eculizumab discontinuation is appropriate in patients with a… Click to show full abstract

Key Points • In CM-TMA, variants in specific genes/regions are associated with high risk of relapse after eculizumab is discontinued.• In CM-TMA, eculizumab discontinuation is appropriate in patients with a low risk of relapse.

Keywords: effect relapse; complement; relapse; complement gene; gene variant; variant effect

Journal Title: Blood Advances
Year Published: 2022

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