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Key Points Patients with FLT3-mutated R/R AML benefitted from gilteritinib regardless of comutations, FLT3-ITD allelic ratio, or FLT3-ITD length. Resistance to gilteritinib was associated with acquired Ras/MAPK pathway gene mutations… Click to show full abstract
Key Points Patients with FLT3-mutated R/R AML benefitted from gilteritinib regardless of comutations, FLT3-ITD allelic ratio, or FLT3-ITD length. Resistance to gilteritinib was associated with acquired Ras/MAPK pathway gene mutations and FLT3 F691L mutations.
Keywords:
flt3;
molecular profile;
flt3 mutated;
mutated relapsed;
relapsed refractory;
profile flt3
Journal Title: Blood Advances
Year Published: 2022
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Journal Title: Blood Advances
Year Published: 2022
Link to full text (if available)
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recommendations!