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Key Points A 20-residue region in domain 6 of HK plays a critical role in Aβ42-induced contact system activation. 3E8 blocks PK and FXI binding to HK, disassembles HK/PK and… Click to show full abstract
Key Points A 20-residue region in domain 6 of HK plays a critical role in Aβ42-induced contact system activation. 3E8 blocks PK and FXI binding to HK, disassembles HK/PK and HK/FXI complexes, and delays intrinsic coagulation.
Keywords:
residue region;
system activation;
contact system
Journal Title: Blood Advances
Year Published: 2022
Link to full text (if available)
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Journal Title: Blood Advances
Year Published: 2022
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!