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Clinical activity of single-dose systemic oncolytic VSV virotherapy in patients with relapsed refractory T-cell lymphoma

Key Points One intravenous dose of oncolytic VSV has single-agent activity in patients with relapsed refractory T-cell lymphoma. Direct oncolytic tumor cell killing and subsequent immune cell activation were observed,… Click to show full abstract

Key Points One intravenous dose of oncolytic VSV has single-agent activity in patients with relapsed refractory T-cell lymphoma. Direct oncolytic tumor cell killing and subsequent immune cell activation were observed, resulting in durable remissions in responding patients.

Keywords: cell; oncolytic vsv; cell lymphoma; relapsed refractory; refractory cell; patients relapsed

Journal Title: Blood Advances
Year Published: 2022

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