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High surface IgM levels associate with shorter response to ibrutinib and BTK bypass in patients with CLL

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Key Points High surface IgM expression associates with shorter time to new treatment following ibrutinib therapy. Cells with high surface IgM expression retain residual signaling capacity downstream of BTK during… Click to show full abstract

Key Points High surface IgM expression associates with shorter time to new treatment following ibrutinib therapy. Cells with high surface IgM expression retain residual signaling capacity downstream of BTK during ibrutinib therapy.

Keywords: surface igm; ibrutinib; high surface; levels associate; igm levels

Journal Title: Blood Advances
Year Published: 2022

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