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Key Points • PUM1, an RNA-binding protein, is a novel target of EKLF that binds to fetal γ-globin mRNA and impairs its stability and translation.• Elevated HbF levels are observed… Click to show full abstract
Key Points • PUM1, an RNA-binding protein, is a novel target of EKLF that binds to fetal γ-globin mRNA and impairs its stability and translation.• Elevated HbF levels are observed upon PUM1 knockdown ex vivo and in an individual harboring a novel PUM1 mutation in the RNA-binding domain.
Keywords:
mediates posttranscriptional;
human fetal;
posttranscriptional regulation;
pum1 mediates;
regulation human;
fetal hemoglobin
Journal Title: Blood Advances
Year Published: 2022
Link to full text (if available)
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Journal Title: Blood Advances
Year Published: 2022
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!