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Key Points • The fetal-to-adult transition in HSC states is associated with a global acquisition of megakaryocytic chromatin accessibility signatures.• The developmentally restricted expression of LIN28B suppresses establishment of an… Click to show full abstract
Key Points • The fetal-to-adult transition in HSC states is associated with a global acquisition of megakaryocytic chromatin accessibility signatures.• The developmentally restricted expression of LIN28B suppresses establishment of an Mk-biased HSC pool early in life.
Keywords:
megakaryocyte priming;
developmental cues;
murine hematopoietic;
cues license;
license megakaryocyte;
priming murine
Journal Title: Blood Advances
Year Published: 2022
Link to full text (if available)
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Journal Title: Blood Advances
Year Published: 2022
Link to full text (if available)
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recommendations!