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Overlapping and unique substrate specificities of ST3GAL1 and 2 during hematopoietic and megakaryocytic differentiation

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Key Points ST3GAL1 and ST3GAL2 have both overlapping and unique substrate specificities in O-glycan sialylation during megakaryopoiesis. O-glycan sialylation is dispensable for MK production but indispensable for MK proplatelet formation. Click to show full abstract

Key Points ST3GAL1 and ST3GAL2 have both overlapping and unique substrate specificities in O-glycan sialylation during megakaryopoiesis. O-glycan sialylation is dispensable for MK production but indispensable for MK proplatelet formation.

Keywords: specificities st3gal1; unique substrate; overlapping unique; st3gal1 hematopoietic; substrate specificities

Journal Title: Blood Advances
Year Published: 2022

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