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Dominant epitopes presented by prevalent HLA alleles permit wide use of banked CMVpp65 T cells in adoptive therapy

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Key Points Dominance of epitopes presented by prevalent HLA alleles permits use of banked CMVpp65CTLs in >90% of transplant recipients. Immunodominant CMVpp65CTLs restricted by HLA B35 alleles fail to lyse… Click to show full abstract

Key Points Dominance of epitopes presented by prevalent HLA alleles permits use of banked CMVpp65CTLs in >90% of transplant recipients. Immunodominant CMVpp65CTLs restricted by HLA B35 alleles fail to lyse infected cells in vitro or control infection in vivo.

Keywords: hla alleles; epitopes presented; prevalent hla; presented prevalent; use banked

Journal Title: Blood Advances
Year Published: 2022

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