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Alterations in B- and circulating T-follicular helper cell subsets in immune thrombotic thrombocytopenic purpura

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Key Points Abnormal B-cell phenotype in acute iTTP with decreased transitional and post–germinal center memory cells and increased plasmablasts. Decreased total and PD1+ circulating T-follicular helper cells and changes in… Click to show full abstract

Key Points Abnormal B-cell phenotype in acute iTTP with decreased transitional and post–germinal center memory cells and increased plasmablasts. Decreased total and PD1+ circulating T-follicular helper cells and changes in B-cell CD80 expression suggest altered B- and T-cell interactions.

Keywords: cell; follicular helper; helper cell; circulating follicular; alterations circulating

Journal Title: Blood Advances
Year Published: 2022

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