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Key Points • HDAC1 inhibition dampens IRF4 transcription through histone hyperacetylation, thereby reducing the expression of the survival mediator PIM2.• Simultaneous targeting of the intrinsic HDAC1-IRF4 axis plus externally activated… Click to show full abstract
Key Points • HDAC1 inhibition dampens IRF4 transcription through histone hyperacetylation, thereby reducing the expression of the survival mediator PIM2.• Simultaneous targeting of the intrinsic HDAC1-IRF4 axis plus externally activated PIM2 represents an efficient therapeutic option for MM.
Keywords:
irf4 axis;
therapeutic option;
inhibition;
hdac1 irf4
Journal Title: Blood Advances
Year Published: 2022
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Journal Title: Blood Advances
Year Published: 2022
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!