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Landscape of immunoglobulin heavy chain gene repertoire and its clinical relevance to LPL/WM

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Key Points We unveil the distinct patterns of IGHV repertoire and discuss the correlation between IGHV and other genetic abnormalities in LPL/WM. IGHV4 usage was a predictive marker of shorter… Click to show full abstract

Key Points We unveil the distinct patterns of IGHV repertoire and discuss the correlation between IGHV and other genetic abnormalities in LPL/WM. IGHV4 usage was a predictive marker of shorter progression-free survival in patients with LPL/WM.

Keywords: heavy chain; chain gene; gene repertoire; immunoglobulin heavy; landscape immunoglobulin; repertoire clinical

Journal Title: Blood Advances
Year Published: 2022

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