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Pevonedistat plus azacitidine vs azacitidine alone in higher-risk MDS/chronic myelomonocytic leukemia or low-blast-percentage AML

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Key points In the phase 3 PANTHER trial, EFS was similar between arms in the intent-to-treat population and in patients with higher-risk MDS. A signal for improved overall survival for… Click to show full abstract

Key points In the phase 3 PANTHER trial, EFS was similar between arms in the intent-to-treat population and in patients with higher-risk MDS. A signal for improved overall survival for pevonedistat+azacitidine was seen in higher-risk MDS, especially with >3 treatment cycles.

Keywords: risk mds; pevonedistat plus; higher risk; plus azacitidine

Journal Title: Blood Advances
Year Published: 2022

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