Key Points • The PLEKHM1-associated endolysosomal system in MSCs affects BCR-ABL1+ B-ALL progression via release of extracellular vesicles.• B-ALL–derived inflammatory cytokines perpetuate this circuit in MSCs, modify vesicular cargo, and… Click to show full abstract
Key Points • The PLEKHM1-associated endolysosomal system in MSCs affects BCR-ABL1+ B-ALL progression via release of extracellular vesicles.• B-ALL–derived inflammatory cytokines perpetuate this circuit in MSCs, modify vesicular cargo, and promote B-ALL cell signaling and survival.
Keywords:
cell;
mesenchymal stromal;
progression;
impact mesenchymal;
vesicular cargo
Journal Title: Blood Advances
Year Published: 2022
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Journal Title: Blood Advances
Year Published: 2022
Link to full text (if available)
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recommendations!