Key Points • Factors XII and XI drive thrombosis in ECMO. FXII appears to promote organ damage in ECMO independent of thrombin generation.• Thrombin-mediated activation of FXI may overshadow the… Click to show full abstract
Key Points • Factors XII and XI drive thrombosis in ECMO. FXII appears to promote organ damage in ECMO independent of thrombin generation.• Thrombin-mediated activation of FXI may overshadow the role of FXII in ECMO when tissue factor levels are high.
Keywords:
contact system;
targeting contact;
rabbit model;
system rabbit;
model extracorporeal;
extracorporeal membrane
Journal Title: Blood Advances
Year Published: 2022
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Journal Title: Blood Advances
Year Published: 2022
Link to full text (if available)
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recommendations!