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Safety and efficacy of tisagenlecleucel plus pembrolizumab in patients with r/r DLBCL: phase 1b PORTIA study results

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Key Points • The best response rates were observed with pembrolizumab before tisagenlecleucel; however, definitive conclusions cannot be made.• Pembrolizumab did not augment the cellular expansion of tisagenlecleucel but delayed… Click to show full abstract

Key Points • The best response rates were observed with pembrolizumab before tisagenlecleucel; however, definitive conclusions cannot be made.• Pembrolizumab did not augment the cellular expansion of tisagenlecleucel but delayed peak expansion in the day 1 cohort.

Keywords: tisagenlecleucel plus; pembrolizumab patients; plus pembrolizumab; safety efficacy; patients dlbcl; efficacy tisagenlecleucel

Journal Title: Blood Advances
Year Published: 2022

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