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Phase 2 trial of ixazomib, cyclophosphamide, and dexamethasone for previously untreated light chain amyloidosis

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Key Points Ixazomib, cyclophosphamide, and dexamethasone combination achieved hematologic response in 63% of newly diagnosed AL amyloidosis patients. The regimen is characterized with a favorable adverse event profile and should… Click to show full abstract

Key Points Ixazomib, cyclophosphamide, and dexamethasone combination achieved hematologic response in 63% of newly diagnosed AL amyloidosis patients. The regimen is characterized with a favorable adverse event profile and should be explored in other combinations.

Keywords: cyclophosphamide dexamethasone; trial ixazomib; ixazomib cyclophosphamide; phase trial; dexamethasone previously; amyloidosis

Journal Title: Blood Advances
Year Published: 2022

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