Photo by mlabellarte from unsplash
Key Points • Coexistence of the Srsf2 P95H mutation and Runx1 deficiency recapitulates the multilineage hematopoietic defects observed in MDS.• RUNX1 deficiency strikingly alters global splicing patterns and synergizes with… Click to show full abstract
Key Points • Coexistence of the Srsf2 P95H mutation and Runx1 deficiency recapitulates the multilineage hematopoietic defects observed in MDS.• RUNX1 deficiency strikingly alters global splicing patterns and synergizes with the Srsf2 P95H mutation to affect DNA damage response genes.
Keywords:
runx1 deficiency;
multilineage hematopoietic;
hematopoietic defects;
mds runx1;
mutation
Journal Title: Blood Advances
Year Published: 2022
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!
Journal Title: Blood Advances
Year Published: 2022
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!