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Proinflammatory microenvironment promotes lymphoma progression in mice with high megakaryocyte and TPO levels

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Key Points • Increased levels of interleukin 1 were found in the bone marrow fluid of TpoTg mice, whereas levels were lowered in Mpl−/− mice.• A proinflammatory microenvironment promoted Eμ-myc… Click to show full abstract

Key Points • Increased levels of interleukin 1 were found in the bone marrow fluid of TpoTg mice, whereas levels were lowered in Mpl−/− mice.• A proinflammatory microenvironment promoted Eμ-myc lymphoma progression in TpoTg mice with high megakaryocyte and thrombopoietin levels.

Keywords: proinflammatory microenvironment; lymphoma progression; high megakaryocyte; mice high

Journal Title: Blood Advances
Year Published: 2022

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