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FBXW7β isoform drives transcriptional activation of the proinflammatory TNF cluster in human pro-B cells

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Key Points • Previously thought to be restricted to neural tissues, FBXW7β is the predominant FBXW7 isoform in normal and malignant human pro-B cells.• FBXW7β promotes transcriptional activation of the… Click to show full abstract

Key Points • Previously thought to be restricted to neural tissues, FBXW7β is the predominant FBXW7 isoform in normal and malignant human pro-B cells.• FBXW7β promotes transcriptional activation of the proinflammatory gene cluster that contains tumor necrosis factor superfamily members.

Keywords: transcriptional activation; pro cells; human pro; activation proinflammatory; fbxw7 isoform

Journal Title: Blood Advances
Year Published: 2022

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