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Integrated flow cytometry and sequencing to reconstruct evolutionary patterns from dysplasia to acute myeloid leukemia

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Key Points • Targeted sequencing of dysplastic cells and blasts at diagnosis identifies evolutionary patterns from dysplasia to the onset of AML.• Patients with AML may present different clonal involvement… Click to show full abstract

Key Points • Targeted sequencing of dysplastic cells and blasts at diagnosis identifies evolutionary patterns from dysplasia to the onset of AML.• Patients with AML may present different clonal involvement in dysplastic myelo-erythropoiesis, leukemic transformation, and chemoresistance.

Keywords: patterns dysplasia; flow cytometry; integrated flow; evolutionary patterns; cytometry sequencing; sequencing reconstruct

Journal Title: Blood Advances
Year Published: 2022

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